Apigeninidin-enriched Sorghum bicolor (L. Moench) extracts alleviate Aflatoxin B₁-induced dysregulation of male rat hypothalamic-reproductive axis.

ABSTRACT: We examined the protective effect of the apigeninidin (API)-enriched fraction from Sorghum bicolor sheaths extracts (SBE-05, SBE-06, and SBE-07) against aflatoxin B₁ (AFB₁)-induced dysregulation of male rat's reproductive system that may trigger infertility. Male rats (160 ± 12 g) were treated with AFB₁ (50 µg/kg) along with 5 or 10 mg/kg of SBE-05, SBE-06, and SBE-07 for 28 days. Subsequently, we assessed the reproductive hormone-prolactin, FSH, LH, testosterone levels, and testicular function enzymes. Moreover, we examined rats' testes, epididymis, and hypothalamus for oxidative and inflammatory stress biomarkers, caspase-9 activity and tissues pathology. We observed that comparative to AFB₁ alone treated rats, API co-treatment significa

SUBMITTER: Owumi SE 

PROVIDER: S-EPMC9442456 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature