Proposal for a new local recurrence score in patients with recurrent malignant pleural mesothelioma.

ABSTRACT:

Background

Malignant pleural mesothelioma (MPM) is associated with high rates of local recurrence (LR) up to 75%. Second line treatment should be applied tailored to relapse pattern. We aimed to establish a new score for LR pattern with prognostic impact in this observational study of retrospective nature.

Methods

MPM patients with LR after surgery, verified by serial imaging during follow-up visits or biopsy were included in a retrospective analysis using a new local recurrence score (LRS). We divided the thoracic cavity into six sections and calculated the LRS according to the tumor burden. We assessed the impact on survival after recurrence using cox regression model.

Results

From 2001 until 2017, 128 consecutive MPM patients with LR who underwent macroscopic compl

SUBMITTER: Lauk O 

PROVIDER: S-EPMC9442537 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature