Phrenic nerve stimulation in an ovine model with temporary removable pacing leads.

ABSTRACT:

Background

The objective of this study was to assess the feasibility and safety of a novel, removable, surgically implanted, temporary neurostimulation approach involving the distal portion of the phrenic nerve.

Methods

Temporary phrenic nerve pacing electrodes were implanted surgically using an ovine model (4 animals). The primary endpoint was the ability to successfully match the animal's minute-ventilation upon implantation of both phrenic nerve pacers on day 1. Secondary endpoints were successful phrenic neurostimulation by both electrodes 15 and 30 days after initial implantation. We also assessed safe removal of the electrodes at 15 and 30 days after implementation.

Results

In 3 of 4 animals, electrodes were successfully implanted in both right and left phrenic

SUBMITTER: Etienne H 

PROVIDER: S-EPMC9442545 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature