Interferon gamma as an immune modulating adjunct therapy for invasive mucormycosis after severe burn - A case report.

ABSTRACT:

Background

Mucormycosis is a deadly fungal infection that mainly affects severely immunocompromised patients. We report herein the case of a previously immunocompetent adult woman who developed invasive cutaneous mucormycosis after severe burn injuries. Interferon-gamma (IFN-γ) treatment was added after failure of conventional treatment and confirmation of a sustained profound immunodepression. The diagnosis was based on a reduced expression of HLA-DR on monocytes (mHLA-DR), NK lymphopenia and a high proportion of immature neutrophils. The immune-related alterations were longitudinally monitored using panels of immune-related biomarkers.

Results

Initiation of IFN-γ was associated with a rapid clinical improvement and a subsequent healing of mucormycosis infection, with no re

SUBMITTER: Tawfik DM 

PROVIDER: S-EPMC9442803 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature