Increased expression of METTL3 in pancreatic cancer tissues associates with poor survival of the patients.

ABSTRACT:

Background

Methyltransferase-like 3 (METTL3) expression could be found in various normal and cancerous tissues. As of now, the clinical significance of METTL3 expression in human pancreatic cancer (PC) tissues still remains to be understood. Our present study aims to investigate the prognostic value and clinical implications of METTL3 expression in PC tissues.

Methods

The TCGA, GTEx, and GEO public databases were used to study the mRNA expression level of the m⁶A family members and its relationship among PC tissues and normal pancreatic tissue. The immunohistochemistry was used to analyze the difference of METTL3 expression between cancer tissues and adjacent normal tissues. The prognostic value was evaluated by using the Log-rank survival analysis and Cox model a

SUBMITTER: Li Y 

PROVIDER: S-EPMC9442951 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature