Comparison of LPS and MS-induced depressive mouse model: behavior, inflammation and biochemical changes.

ABSTRACT: Depression is a mental disease involving complex pathophysiological mechanisms, and there are many ways to establish depressive mouse models. The purpose of this study is to comprehensively compare the behavioral changes and its mechanism induced by two different models. This study established two depressive mouse models by maternal separation (MS) or lipopolysaccharide (LPS) administration, and added fluoxetine treatment group respectively for comparison. MS induced more apparent anxiety-like behavior while LPS induced more apparent depressive-like behavior. LPS increased peripheral inflammatory factors more apparent, which were mitigated by fluoxetine. MS inhibited the 5-HT system more obviously and was relieved by fluoxetine. LPS triggered stronger immune response in the hippocampus and

SUBMITTER: Yu X 

PROVIDER: S-EPMC9443001 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature