P11.14.A Systematic review of phase III trials in newly diagnosed glioblastoma 2005-2021

ABSTRACT: Abstract

Background

Despite a plethora of studies since the EORTC/NCIC trial in 2005, glioblastoma (GBM) prognosis remains poor. We here identify and compare glioblastoma phase III trials in terms of efficacy and baseline characteristics in an attempt to summarize the experience of the past 16 years.

Methods

A systematic literature search using PubMed and ClinicalTrials.gov was conducted to provide an overview of clinically relevant GBM phase III trials (years 2005-2021) of adult patients younger than 70 years of age. Search results were screened according to predefined inclusion criteria and either excluded or included in further analysis on study design, baseline characteristics, and survival results.

Results

Eleven trials from the literature and clinical trial

SUBMITTER:  

PROVIDER: S-EPMC9443298 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature