Heterogeneous metallaphotoredox catalysis in a continuous-flow packed-bed reactor.

ABSTRACT: Metallaphotoredox catalysis is a powerful and versatile synthetic platform that enables cross-couplings under mild conditions without the need for noble metals. Its growing adoption in drug discovery has translated into an increased interest in sustainable and scalable reaction conditions. Here, we report a continuous-flow approach to metallaphotoredox catalysis using a heterogeneous catalyst that combines the function of a photo- and a nickel catalyst in a single material. The catalyst is embedded in a packed-bed reactor to combine reaction and (catalyst) separation in one step. The use of a packed bed simplifies the translation of optimized batch reaction conditions to continuous flow, as the only components present in the reaction mixture are the substrate and a base. The metallaphotore

SUBMITTER: Hsu WH 

PROVIDER: S-EPMC9443413 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature