Genetic Disruption of KLF1 K74 SUMOylation in Hematopoietic System Promotes Healthy Longevity in Mice.

ABSTRACT: The quest for rejuvenation and prolonged lifespan through transfusion of young blood has been studied for decades with the hope of unlocking the mystery of the key substance(s) that exists in the circulating blood of juvenile organisms. However, a pivotal mediator has yet been identified. Here, atypical findings are presented that are observed in a knockin mouse model carrying a lysine to arginine substitution at residue 74 of Krüppel-like factor 1 (KLF1/EKLF), the SUMOylation-deficient Klf1^K74R/K74R mouse, that displayed significant improvement in geriatric disorders and lifespan extension. Klf1^K74R/K74R mice exhibit a marked delay in age-related physical performance decline and disease progression as evidenced by physiological and pathological examinations. Furtherm

SUBMITTER: Shyu YC 

PROVIDER: S-EPMC9443461 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature