Association between risk polymorphisms for neurodegenerative diseases and cognition in colombian patients with frontotemporal dementia.

ABSTRACT: Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disease of presenile onset. A better characterization of neurodegenerative disorders has been sought by using tools such as genome-wide association studies (GWAS), where associations between single nucleotide polymorphisms (SNPs) and cognitive profiles could constitute predictive biomarkers for these diseases. However, in FTD, associations between genotypes and cognitive phenotypes are yet to be explored. Here, we evaluate a possible relationship between genetic variants and some cognitive functions in an FTD population.

Methodology

A total of 47 SNPs in genes associated with neurodegenerative diseases were evaluated using the Sequenom MassARRAY platform along with their possible relationship with performance in neur

SUBMITTER: Lopez-Caceres A 

PROVIDER: S-EPMC9443520 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature