MtDNA mutations, hearing loss and aminoglycoside treatment in Mexicans.

ABSTRACT:

Unlabelled

Streptomycin and aminoglycoside derivatives are commonly used to treat tuberculosis and other stubborn infections; these drugs may alter auditory and/or vestibular function. Mutations in mitochondrial DNA have been associated with hypersensitivity to aminoglycosides; no studies have been conducted in Mexicans, which are very prone to such alterations because aminoglycosides have been prescribed carelessly for many years, irrespective of the ailment to be treated.

Aim

We investigated "hot spot" mutations described previously as causing inner ear alterations.

Methods

Hot spot mutations at the 12S rRNA gene and the tRNA Serine (UCN) gene were screened by PCR-RFLP and sequencing in 65 subjects undergoing audiological and vestibular testing.

Study design

SUBMITTER: Meza G 

PROVIDER: S-EPMC9443722 | biostudies-literature | 2011 Sep-Oct

REPOSITORIES: biostudies-literature