Vascular endothelial growth factor and its receptors regulation in gestational diabetes mellitus and eclampsia.

ABSTRACT:

Background

An imbalance in the expression of vascular endothelial growth factor (VEGF) and its receptor (VEGF-R) during pregnancy plays an important role in the pathogenesis of gestational diabetes mellitus (GDM) and eclampsia. VEGF and its receptors change during the regulation of blood vessels as a result of risk factors such as familial genetics. These modifications include loss of original balance of serological indicators, upregulation or downregulation of growth factor indicators, and changes in the placenta, kidney, liver and other organs to varying degrees of damage. This has an impact on both the pregnant woman's and the fetus's health.

Main body

This paper summarizes the mechanisms of unbalanced VEGF and receptor expression based on data from relevant literature on

SUBMITTER: Bolatai A 

PROVIDER: S-EPMC9444093 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature