Multidimensional Early Prediction Score for Drug-Resistant Epilepsy.

ABSTRACT:

Background and purpose

Achieving favorable postoperative outcomes in patients with drug-resistant epilepsy (DRE) requires early referrals for preoperative examinations. The purpose of this study was to investigate the possibility of a user-friendly early DRE prediction model that is easy for nonexperts to utilize.

Methods

A two-step genotype analysis was performed, by applying 1) whole-exome sequencing (WES) to the initial test set (n=243) and 2) target sequencing to the validation set (n=311). Based on a multicenter case-control study design using the WES data set, 11 genetic and 2 clinical predictors were selected to develop the DRE risk prediction model. The early prediction scores for DRE (EPS-DRE) was calculated for each group of the selected genetic predi

SUBMITTER: Kang KW 

PROVIDER: S-EPMC9444554 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature