A worldwide survey on the use of animal-derived materials and reagents in scientific experimentation.

ABSTRACT: The use of cell and tissue-based methods in basic, applied and regulatory science has been increasing exponentially. Animal-derived components, including serum, coating materials, growth factors and antibodies are routinely used in cell/tissue cultures and in general laboratory practices. In addition to ethical issues, the use and production of animal-derived materials and reagents raises many scientific concerns, generally associated with presence of undefined components and batch-to-batch variability, which may compromise experimental reproducibility. On the other hand, non-animal materials and reagents, such as human cells, alternatives to animal sera or non-animal recombinant antibodies, are becoming increasingly available, and their use is encouraged by the EU Directive 2010/63 and th

SUBMITTER: Cassotta M 

PROVIDER: S-EPMC9444711 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature