PH-responsive cinnamaldehyde-TiO₂ nanotube coating: fabrication and functions in a simulated diabetes condition.

ABSTRACT: Current evidence has suggested that diabetes increases the risk of implanting failure, and therefore, appropriate surface modification of dental implants in patients with diabetes is crucial. TiO₂ nanotube (TNT) has an osteogenic nanotopography, and its osteogenic properties can be further improved by loading appropriate drugs. Cinnamaldehyde (CIN) has been proven to have osteogenic, anti-inflammatory, and anti-bacterial effects. We fabricated a pH-responsive cinnamaldehyde-TiO₂ nanotube coating (TNT-CIN) and hypothesized that this coating will exert osteogenic, anti-inflammatory, and anti-bacterial functions in a simulated diabetes condition. TNT-CIN was constructed by anodic oxidation, hydroxylation, silylation, and Schiff base reaction to bind CIN, and its surface

SUBMITTER: Lee Y 

PROVIDER: S-EPMC9444834 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature