The Association of Early Corticosteroid Therapy With Clinical and Health-Related Quality of Life Outcomes in Children With Septic Shock.

ABSTRACT:

Objectives

Corticosteroids are commonly used in the treatment of pediatric septic shock without clear evidence of the potential benefits or risks. This study examined the association of early corticosteroid therapy with patient-centered clinically meaningful outcomes.

Design

Subsequent cohort analysis of data derived from the prospective Life After Pediatric Sepsis Evaluation (LAPSE) investigation. Outcomes among patients receiving hydrocortisone or methylprednisolone on study day 0 or 1 were compared with those who did not use a propensity score-weighted analysis that controlled for age, sex, study site, and measures of first-day illness severity.

Setting

Twelve academic PICUs in the United States.

Patients

Children with community-acquired septic shock 1 month

SUBMITTER: Kamps NN 

PROVIDER: S-EPMC9444900 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature