Postacute sequelae and adaptive immune responses in people with HIV recovering from SARS-COV-2 infection.

ABSTRACT:

Background

Limited data are available on the long-term clinical and immunologic consequences of SARS-CoV-2 infection in people with HIV (PWH).

Methods

We measured SARS-CoV-2-specific humoral and cellular responses in people with and without HIV recovering from COVID-19 ( n  = 39 and n  = 43, respectively) using binding antibody, surrogate virus neutralization, intracellular cytokine staining, and inflammatory marker assays. We identified individuals experiencing postacute sequelae of SARS-CoV-2 infection (PASC) and evaluated immunologic parameters. We used linear regression and generalized linear models to examine differences by HIV status in the magnitude of inflammatory and virus-specific antibody and T-cell responses, as well as differences in the prevalence of PASC.

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SUBMITTER: Peluso MJ 

PROVIDER: S-EPMC9444925 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature