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Shining a FLASHlight on Ultrahigh Dose-Rate Radiation and Possible Late Toxicity.


ABSTRACT: A recent study reported results from a clinical trial in cats and from experiments in mini-pigs in which a single dose of radiotherapy was delivered at ultrahigh dose rates (FLASH). There was acceptable acute toxicity; however, some animals suffered severe late toxicity, raising caution in the design of future trials. See related article by Rohrer Bley et al., p. 3814.

SUBMITTER: Maity A 

PROVIDER: S-EPMC9444945 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Shining a FLASHlight on Ultrahigh Dose-Rate Radiation and Possible Late Toxicity.

Maity Amit A   Koumenis Constantinos C  

Clinical cancer research : an official journal of the American Association for Cancer Research 20220901 17


A recent study reported results from a clinical trial in cats and from experiments in mini-pigs in which a single dose of radiotherapy was delivered at ultrahigh dose rates (FLASH). There was acceptable acute toxicity; however, some animals suffered severe late toxicity, raising caution in the design of future trials. See related article by Rohrer Bley et al., p. 3814. ...[more]

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