Time restricted feeding decreases renal innate immune cells and blood pressure in hypertensive mice.

ABSTRACT:

Background

Renal innate immune cell accumulation and inflammation are associated with hypertension. Time restricted feeding (TRF) has been reported to decrease inflammation and blood pressure. Whether TRF can decrease blood pressure by decreasing renal innate immune cells in hypertension is unknown.

Methods and results

We determined whether TRF can decrease blood pressure in two separate mouse models of hypertension, N(G)-nitro-L-arginine methyl ester hydrochloride-induced hypertension (LHTN) and salt-sensitive hypertension (SSHTN). Once hypertension was established after 2 days, TRF (12-h food/12-h no food) for 4 weeks significantly decreased systolic blood pressure in both LHTN and SSHTN mice despite no differences in the amount of food eaten or body weight between groups.

SUBMITTER: Sims BM 

PROVIDER: S-EPMC9444961 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature