Optimal imaging time points considering accuracy and precision of Patlak linearization for ⁸⁹Zr-immuno-PET: a simulation study.

ABSTRACT:

Purpose

Zirconium-89-immuno-positron emission tomography (⁸⁹Zr-immuno-PET) has enabled visualization of zirconium-89 labelled monoclonal antibody (⁸⁹Zr-mAb) uptake in organs and tumors in vivo. Patlak linearization of ⁸⁹Zr-immuno-PET quantification data allows for separation of reversible and irreversible uptake, by combining multiple blood samples and PET images at different days. As one can obtain only a limited number of blood samples and scans per patient, choosing the optimal time points is important. Tissue activity concentration curves were simulated to evaluate the effect of imaging time points on Patlak results, considering different time points, input functions, noise levels and levels of reversible and irreversible uptake.

Methods

SUBMITTER: Wijngaarden JE 

PROVIDER: S-EPMC9445120 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature