Identification of potential biomarkers of inflammation-related genes for ischemic cardiomyopathy.

ABSTRACT:

Objective

Inflammation plays an important role in the pathophysiology of ischemic cardiomyopathy (ICM). We aimed to identify potential biomarkers of inflammation-related genes for ICM and build a model based on the potential biomarkers for the diagnosis of ICM.

Materials and methods

The microarray datasets and RNA-Sequencing datasets of human ICM were downloaded from the Gene Expression Omnibus database. We integrated 8 microarray datasets via the SVA package to screen the differentially expressed genes (DEGs) between ICM and non-failing control samples, then the differentially expressed inflammation-related genes (DEIRGs) were identified. The least absolute shrinkage and selection operator, support vector machine recursive feature elimination, and random forest were

SUBMITTER: Wang J 

PROVIDER: S-EPMC9445158 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature