Causal relationships of obesity on musculoskeletal chronic pain: A two-sample Mendelian randomization study.

ABSTRACT:

Background

The association between obesity and musculoskeletal chronic pain has attracted much attention these days; however, the causal relationship between them is uncertain. Hence, this study performed a Mendelian randomization (MR) analysis to investigate the causal effects of body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) on knee pain, hip pain, and back pain.

Materials and methods

The summary data for obesity and musculoskeletal chronic pain came from the genome-wide association study datasets. Significant and independent (p < 5 × 10^-8; r² < 0.001, kb = 10,000) single-nucleotide polymorphisms were extracted for MR analysis. The inverse variance weighted (IVW) and other methods were used

SUBMITTER: Chen X 

PROVIDER: S-EPMC9445165 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature