Astrogliosis in aging and Parkinson's disease dementia: a new clinical study with ¹¹C-BU99008 PET.

ABSTRACT: The role of astrogliosis in the pathology of brain aging and neurodegenerative diseases has recently drawn great attention. Imidazoline-2 binding sites represent a possible target to map the distribution of reactive astrocytes. In this study, we use ¹¹C-BU99008, an imidazoline-2 binding sites-specific PET radioligand, to image reactive astrocytes in vivo in healthy controls and patients with established Parkinson's disease dementia. Eighteen healthy controls (age: 45-78 years) and six patients with Parkinson's disease dementia (age: 64-77 years) had one ¹¹C-BU99008 PET-CT scan with arterial input function. All subjects underwent one 3 T MRI brain scan to facilitate the analysis of the PET data and to capture individual cerebral atrophy. Regional ¹¹C-

SUBMITTER: Mohamed MA 

PROVIDER: S-EPMC9445175 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature