Effectiveness and toxicity of metronomic oral cyclophosphamide for recurrent or platinum-refractory ovarian cancer: A meta-analysis.

ABSTRACT:

Purpose

To systematically assess the effectiveness and toxicity of metronomic oral cyclophosphamide (MOC) on recurrent or platinum-refractory ovarian cancer.

Methods

We searched the Cochrane Library, Embase, PubMed, CNKI, Weipu, and Wanfang databases for eligible studies. A descriptive statistical method was used to analyze the pooled results. Ratios and means were merged to analyze the objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and the rate of serious adverse events (SAEs). Subgroup analysis, sensitivity analysis, and examination of publication bias were conducted for heterogeneity test and quality assurance of the results.

Results

The ORR and DCR by MOC were 25% (95% CI 12-41) and 61% (95% CI 43

SUBMITTER: Huang L 

PROVIDER: S-EPMC9445287 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature