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ABSTRACT: Background
In this systematic review we sought to characterize practice effects on traditional in-clinic or digital performance outcome measures commonly used in one of four neurologic disease areas (multiple sclerosis; Huntington's disease; Parkinson's disease; and Alzheimer's disease, mild cognitive impairment and other forms of dementia), describe mitigation strategies to minimize their impact on data interpretation and identify gaps to be addressed in future work.Methods
Fifty-eight original articles (49 from Embase and an additional 4 from PubMed and 5 from additional sources; cut-off date January 13, 2021) describing practice effects or their mitigation strategies were included.Results
Practice effects observed in healthy volunteers do not always translate to
SUBMITTER: Holm SP
PROVIDER: S-EPMC9445299 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature