Endothelial Responses to Curvature-Induced Flow Patterns in Engineered Cerebral Aneurysms.

ABSTRACT: Hemodynamic factors have long been associated with clinical outcomes in the treatment of cerebral aneurysms. Computational studies of cerebral aneurysm hemodynamics have provided valuable estimates of the mechanical environment experienced by the endothelium in both the parent vessel and aneurysmal dome walls and have correlated them with disease state. These computational-clinical studies have recently been correlated with the response of endothelial cells (EC) using either idealized or patient-specific models. Here, we present a robust workflow for generating anatomic-scale aneurysm models, establishing luminal cultures of ECs at physiological relevant flow profiles, and comparing EC responses to curvature mediated flow. We show that flow patterns induced by parent vessel curvature produ

SUBMITTER: Mandrycky CJ 

PROVIDER: S-EPMC9445320 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature