Myelin damage and cortical atrophy in watershed regions in patients with moyamoya angiopathy.

ABSTRACT:

Background

Despite it being known that chronic ischemia results in myelin damage and gray matter atrophy, data regarding patients with moyamoya angiopathy is limited. We hypothesized that chronic ischemia in moyamoya angiopathy leads to myelin damage, especially in anterior watershed regions, as well as cortical atrophy in these areas.

Materials and methods

Twenty adult patients with moyamoya angiopathy and 17 age- and sex-matched healthy controls were evaluated using the T1w/T2w mapping method and surface-based MR-morphometry. The T1w/T2w signal intensity ratio, which reflects the white matter integrity, and the cortical thickness, were calculated in watershed regions and compared between the patients and controls. In the patients with moyamoya angiopathy, the correlations

SUBMITTER: Filimonova E 

PROVIDER: S-EPMC9445365 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature