Implications of regulatory T cells in anti-cancer immunity: from pathogenesis to therapeutics.

ABSTRACT: Regulatory T cells (Tregs) play an essential role in maintaining immune tolerance and suppressing inflammation. However, Tregs present major hurdle in eliciting potent anti-cancer immune responses. Therefore, curbing the activity of Tregs represents a novel and efficient way towards successful immunotherapy of cancer. Moreover, there is an emerging interest in harnessing Treg-based strategies for augmenting anti-cancer immunity in different types of the disease. This review summarises the crucial mechanisms of Tregs' mediated suppression of anti-cancer immunity and strategies to suppress or to alter such Tregs to improve the immune response against tumors. Highlighting important clinical studies, the review also describes current Treg-based therapeutic interventions in cancer, and discusse

SUBMITTER: Dwivedi M 

PROVIDER: S-EPMC9445387 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature