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Case series of nebulizing r-tPA for COVID-19 induced acute respiratory distress syndrome.

ABSTRACT: Fibrin deposition in the alveolar spaces during pulmonary involvement of COVID-19 impairs the O₂/CO₂ exchange and leads to respiratory symptoms. In this report, Recombinant Tissue Plasminogen Activator (r-tPA) has been nebulized to 3 critically ill COVID-19 patients in order to resolve the deposited fibrin while avoiding the risk of bleeding. Based on these observations, nebulization of r-tPA may be a potential therapeutic approach and new area of research for future studies.

SUBMITTER: Amini S

PROVIDER: S-EPMC9445426 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Case series of nebulizing r-tPA for COVID-19 induced acute respiratory distress syndrome.

Amini Shahideh S Labbani-Motlagh Zohre Z Aliannejad Rasoul R Pourabbas Seyed Mohammad SM Vasei Mohammad M

Clinical case reports 20220905 9

Fibrin deposition in the alveolar spaces during pulmonary involvement of COVID-19 impairs the O<sub>2</sub>/CO<sub>2</sub> exchange and leads to respiratory symptoms. In this report, Recombinant Tissue Plasminogen Activator (r-tPA) has been nebulized to 3 critically ill COVID-19 patients in order to resolve the deposited fibrin while avoiding the risk of bleeding. Based on these observations, nebulization of r-tPA may be a potential therapeutic approach and new area of research for future studie ...[more]

PMID: 36093444

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