Controlled vitamin D delivery with injectable hyaluronic acid-based hydrogel for restoration of tendinopathy.

ABSTRACT: Tendinopathy is a term used to describe tendon disorders that are marked by pain and a loss of function. Recent studies demonstrated that inflammation plays an important role throughout the broad spectrum of tendinopathy. Conventional treatments such as steroid injections, analgesics, and physical modalities simply give pain relief and do not alter the disease progression without the tendon regeneration effect. Tenocytes are responsible for maintaining the tendon matrix and understanding how they function is essential to studying new treatments for tendinopathy. Our previous study showed the protective effects of vitamin D (Vit D) on damaged tenocytes. Besides its well-known effects on bone metabolism, the non-classical action of Vit D is the pleiotropic effects on modulating immune functi

SUBMITTER: Kim DS 

PROVIDER: S-EPMC9445534 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature