Apolipoprotein E mimetic peptide COG1410 combats pandrug-resistant Acinetobacter baumannii.

ABSTRACT: The emergence of pandrug-resistant bacteria breaks through the last line of defense and raises fear among people of incurable infections. In the post-antibiotic era, the pharmaceutical field turns to seek non-conventional anti-infective agents. Antimicrobial peptides are considered a prospective solution to the crisis of antimicrobial resistance. In this study, we evaluated the antimicrobial efficiency of an ApoE mimetic peptide, COG1410, which has been confirmed to exhibit strong neural protective activity and immunomodulatory function. COG1410 showed potent antimicrobial activity against pandrug-resistant Acinetobacter baumannii, even eliminating large inocula (10⁸ CFU/ml) within 30 min. LC_99.9 in PBS and 50% pooled human plasma was 2 μg/ml (1.4 μM) and 8 μg/

SUBMITTER: Wang B 

PROVIDER: S-EPMC9445589 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature