Developing a risk stratification tool for predicting opioid-related respiratory depression after non-cardiac surgery: a retrospective study.

ABSTRACT:

Objectives

Accurately assessing the probability of significant respiratory depression following opioid administration can potentially enhance perioperative risk assessment and pain management. We developed and validated a risk prediction tool to estimate the probability of significant respiratory depression (indexed by naloxone administration) in patients undergoing noncardiac surgery.

Design

Retrospective cohort study.

Setting

Single academic centre.

Participants

We studied n=63 084 patients (mean age 47.1±18.2 years; 50% men) who underwent emergency or elective non-cardiac surgery between 1 January 2007 and 30 October 2017.

Interventions

A derivation subsample reflecting two-thirds of available patients (n=42 082) was randomly selected for model develo

SUBMITTER: Roy S 

PROVIDER: S-EPMC9445779 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature