Dementia clinical trials over the past decade: are women fairly represented?

ABSTRACT:

Background

Lack of progress in finding disease-modifying treatments for dementia may be due to heterogeneity in treatment effects among subgroups, such as by sex. Therefore, we investigated the characteristics of dementia trials completed in the last decade, with a focus on women's representation and sex-disaggregated outcomes.

Methods

Clinical trials on dementia completed since 2010 were identified from ClinicalTrials.gov. Randomised, phase III/IV trials with ≥100 participants were selected to quantify women's representation among participants, by computing the participation to prevalence ratio (PPR) and investigate whether sex-disaggregated analyses had been performed.

Results

A total of 1351 trials were identified between January 2010 and August 2021 (429 520 parti

SUBMITTER: Pinho-Gomes AC 

PROVIDER: S-EPMC9445798 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature