MRI markers of brain network integrity relate to neurological outcome in postanoxic coma.

ABSTRACT:

Aim

Current multimodal approaches leave approximately half of the comatose patients after cardiac arrest with an indeterminate prognosis. Here we investigated whether early MRI markers of brain network integrity can distinguish between comatose patients with a good versus poor neurological outcome six months later.

Methods

We performed a prospective cohort study in 48 patients after cardiac arrest submitted in a comatose state to the Intensive Care Unit of two Dutch hospitals. MRI was performed at three days after cardiac arrest, including resting state functional MRI and diffusion-tensor imaging (DTI). Resting state fMRI was used to quantify functional connectivity within ten resting-state networks, and DTI to assess mean diffusivity (MD) in these same networks. We contrast

SUBMITTER: Keijzer HM 

PROVIDER: S-EPMC9446009 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature