Trans-differentiation of mouse mesenchymal stem cells into pancreatic β-like cells by a traditional anti-diabetic medicinal herb Medicago sativa L.

ABSTRACT:

Background and aim

Medicago sativa L. is a medicinal herb first cultivated in ancient Iran. Traditionally, it has been utilized for the treatment of several disorders. The plant has been in the human diet for at least 1500 years. Although the hypoglycaemic and anti-diabetic effects of the plant have been approved in traditional medicine, further investigations are needed to support the rational use of M. sativa by humans. This project aimed to evaluate the trans-differentiation potential of bone marrow mesenchymal stem cells (MSCs) to pancreatic β-like cells (insulin-producing cells; IPCs) under the influence of M. sativa extract.

Experimental procedure

Bone marrow MSCs isolated, characterized, and then treated by flower or leaf extract of M. s

SUBMITTER: Mansourzadeh S 

PROVIDER: S-EPMC9446024 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature