Nonparticipation reasons in a randomized international trial of a new latent tuberculosis infection regimen.

ABSTRACT:

Background/aims

Efficient recruitment of eligible participants, optimizing time and sample size, is a crucial component in conducting a successful clinical trial. Inefficient participant recruitment can impede study progress, consume staff time and resources, and limit quality and generalizability or the power to assess outcomes. Recruitment for disease prevention trials poses additional challenges because patients are asymptomatic. We evaluated candidates for a disease prevention trial to determine reasons for nonparticipation and to identify factors that can be addressed to improve recruitment efficiency.

Methods

During 2001-2009, the Tuberculosis Trials Consortium conducted Study 26 (PREVENT TB), a randomized clinical trial at 26 sites in four countries, among persons wit

SUBMITTER: Hedges KNC 

PROVIDER: S-EPMC9446162 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature