Early life trauma and adult leucocyte telomere length.

ABSTRACT:

Background

Telomere length, a biomarker of cell division and cellular aging, has been associated with multiple chronic disease endpoints. Experienced trauma over the life course may contribute to telomere shortening via mechanisms of stress embodiment. However, it is unclear how patterns of co-occurring trauma during sensitive periods (e.g., early life) throughout the life course may influence telomere shortening. We examine the relationship between co-occurring early life trauma on adult telomere length and the extent to which adulthood trauma, socioeconomic position, and health and lifestyle factors may mediate this relationship.

Methods

We use data from a sample of participants in the Sister Study (N = 740, analytic sample: n = 602), a prospective cohort of U.S. self-iden

SUBMITTER: Woo JMP 

PROVIDER: S-EPMC9446387 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature