Tetraplegia is associated with increased hypoxic ventilatory response during nonrapid eye movement sleep.

ABSTRACT: People with cervical spinal cord injury (SCI) are likely to experience chronic intermittent hypoxia while sleeping. The physiological effects of intermittent hypoxia on the respiratory system during spontaneous sleep in individuals with chronic cervical SCI are unknown. We hypothesized that individuals with cervical SCI would demonstrate higher short- and long-term ventilatory responses to acute intermittent hypoxia (AIH) exposure than individuals with thoracic SCI during sleep. Twenty participants (10 with cervical SCI [9 male] and 10 with thoracic SCI [6 male]) underwent an AIH and sham protocol during sleep. During the AIH protocol, each participant experienced 15 episodes of isocapnic hypoxia using mixed gases of 100% nitrogen (N₂ ) and 40% carbon dioxide (CO₂ ) t

SUBMITTER: Vaughan S 

PROVIDER: S-EPMC9446393 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature