Lung- and liver-dominant phenotypes of Korean eight constitution medicine have different profiles of genotype associated with each organ function.

ABSTRACT: Eight Constitution Medicine (ECM), a ramification of traditional Korean medicine, has categorized people into eight constitutions. The main criteria of classification are inherited differences or predominance in the functions of organs, such as the liver or lung, diagnosed through ECM-specific pulse patterns. This study investigated the association between single nucleotide polymorphism (SNP) genotypes and ECM phenotypes and explored candidate genetic makeups responsible for each constitution using a genome-wide association study (GWAS). Sixty-three healthy volunteers, who were either categorized as the Hepatonia (HEP, n = 32) or Pulmotonia (PUL, n = 31) constitution, were enrolled. HEP and PUL are two contrasting ECM types representing the dominant liver and lung phenotypes, respectively.

SUBMITTER: Kim C 

PROVIDER: S-EPMC9446411 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature