Characterization of the fatty acid profile in the ventral midbrain of mice exposed to dietary imbalance between omega-6 and omega-3 fatty acids during specific life stages.

ABSTRACT:

Objective

Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are essential nutrients. Dietary imbalance between these PUFAs, in particular high in n-6 PUFAs and low in n-3 PUFAs (n-6^high/n-3^low), is common in modern society. We have previously reported that C57BL/6 mouse male offspring derived from mothers exposed to an n-6^high/n-3^low diet during the gestation had an augmented ventral midbrain dopamine system in adulthood; however, the fatty acid composition in this brain region has not yet been investigated. This follow-up study aims to characterize the fatty acid profile of the ventral midbrain of mice exposed to the n-6^high/n-3^low diet during specific life stages.

Results

n-6 PUFAs, especia

SUBMITTER: Sakayori N 

PROVIDER: S-EPMC9446585 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature