Transcriptional dynamics of transposable elements in the type I IFN response in Myotis lucifugus cells.

ABSTRACT:

Background

Bats are a major reservoir of zoonotic viruses, and there has been growing interest in characterizing bat-specific features of innate immunity and inflammation. Recent studies have revealed bat-specific adaptations affecting interferon (IFN) signaling and IFN-stimulated genes (ISGs), but we still have a limited understanding of the genetic mechanisms that have shaped the evolution of bat immunity. Here we investigated the transcriptional and epigenetic dynamics of transposable elements (TEs) during the type I IFN response in little brown bat (Myotis lucifugus) primary embryonic fibroblast cells, using RNA-seq and CUT&RUN.

Results

We found multiple bat-specific TEs that undergo both locus-specific and family-level transcriptional induction in response to IFN. Our t

SUBMITTER: Pasquesi GIM 

PROVIDER: S-EPMC9446614 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature