Efficacy of stem cell therapy in animal models of intracerebral hemorrhage: an updated meta-analysis.

ABSTRACT:

Background

Multiple studies have reported that stem cell therapy has beneficial effects in animal models of intracerebral hemorrhage (ICH). However, this finding remains inconclusive. This study was performed to systematically determine the effect size of stem cell therapy in ICH animal models by pooling and analyzing data from newly published studies.

Methods

A literature search identified studies of stem cells in animal models of ICH. We searched mainstream databases from inception to November, 2021. And pooled effect size of stem cells was determined for diversified neurobehavioral scales and structural endpoints using random effects models.

Results

The median quality score of 62 included studies was 5.32. Our results revealed an overall positive effect of stem cel

SUBMITTER: Li C 

PROVIDER: S-EPMC9446670 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature