Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting.

ABSTRACT:

Background

The role of germline genetic factors in determining survival from cutaneous melanoma (CM) is not well understood.

Objective

To perform a genome-wide association study (GWAS) meta-analysis of melanoma-specific survival (MSS), and test whether a CM-susceptibility polygenic risk score (PRS) is associated with MSS.

Methods

We conducted two Cox proportional-hazard GWAS of MSS using data from the Melanoma Institute Australia, a high ultraviolet (UV) radiation setting (MIA; 5,762 patients with melanoma; 800 melanoma deaths) and UK Biobank (UKB: 5,220 patients with melanoma; 241 melanoma deaths), and combined them in a fixed-effects meta-analysis. Significant (P < 5 × 10-8) results were investigated in the Leeds Melanoma Cohort (LMC; 1,947 patients with melanoma; 3

SUBMITTER: Seviiri M 

PROVIDER: S-EPMC9446843 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature