Pseudo Pelger-Huet anomalies as potential biomarkers for acute exposure radiation dose in rhesus macaques (Macaca mulatta).

ABSTRACT:

Purpose

The potential for malicious use of radiation, or radiation accidents could potentially lead to acute, high radiation doses to the public. Following acute accidental exposure to high doses of radiation, medical intervention is pivotal to the survivability of the patient, and the sooner the appropriate measures are taken the better the odds for survival. Early estimates of acute accidental radiation doses can be determined via biomarkers such as dicentric chromosome analysis or scenario reconstruction using computer software. However, both take valuable time and can be expensive. Increased frequencies of abnormal neutrophils in peripheral blood, referred to as pseudo Pelger-Huët anomalies (PPHAs), have been shown to be potential biomarkers of radiation exposure in several sce

SUBMITTER: Hayes JM 

PROVIDER: S-EPMC9446855 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature