Atrial myocyte-derived exosomal microRNA contributes to atrial fibrosis in atrial fibrillation.

ABSTRACT:

Background

Atrial fibrosis plays a critical role in the development of atrial fibrillation (AF). Exosomes are a promising cell-free therapeutic approach for the treatment of AF. The purposes of this study were to explore the mechanisms by which exosomes derived from atrial myocytes regulate atrial remodeling and to determine whether their manipulation facilitates the therapeutic modulation of potential fibrotic abnormalities during AF.

Methods

We isolated exosomes from atrial myocytes and patient serum, and microRNA (miRNA) sequencing was used to analyze exosomal miRNAs in exosomes derived from atrial myocytes and patient serum. mRNA sequencing and bioinformatics analyses corroborated the key genes that were direct targets of miR-210-3p.

Results

The miRNA sequencing a

SUBMITTER: Hao H 

PROVIDER: S-EPMC9446866 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature