Zinc(II) Complex with Pyrazolone-Based Hydrazones is Strongly Effective against Trypanosoma brucei Which Causes African Sleeping Sickness.

ABSTRACT: Two pyrazolone-based hydrazones H₂L' [in general, H₂L'; in detail, H₂L¹ = 5-methyl-2-phenyl-4-(2-phenyl-1-(2-(4-(trifluoromethyl)phenyl)hydrazineyl)ethyl)-2,4-dihydro-3H-pyrazol-3-one, H₂L² = (Z)-5-methyl-2-phenyl-4-(2-phenyl-1-(2-(pyridin-2-yl)hydrazineyl)ethylidene)-2,4-dihydro-3H-pyrazol-3-one] were reacted with Zn(II) and Cu(II) acceptors affording the complexes [Zn(HL¹)₂(MeOH)₂], [Cu(HL¹)₂], and [M(HL²)₂] (M = Cu or Zn). X-ray and DFT studies showed the free proligands to exist in the N-H,N-H tautomeric form and that in [Zn(HL¹)₂(MeOH)₂

SUBMITTER: Marchetti F 

PROVIDER: S-EPMC9446893 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature