Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth.

ABSTRACT: Lysosomes must maintain the integrity of their limiting membrane to ensure efficient fusion with incoming organelles and degradation of substrates within their lumen. Pancreatic cancer cells upregulate lysosomal biogenesis to enhance nutrient recycling and stress resistance, but it is unknown whether dedicated programmes for maintaining the integrity of the lysosome membrane facilitate pancreatic cancer growth. Using proteomic-based organelle profiling, we identify the Ferlin family plasma membrane repair factor Myoferlin as selectively and highly enriched on the membrane of pancreatic cancer lysosomes. Mechanistically, lysosomal localization of Myoferlin is necessary and sufficient for the maintenance of lysosome health and provides an early acting protective system against membrane damag

SUBMITTER: Gupta S 

PROVIDER: S-EPMC9446896 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature