Historical Contingency Drives Compensatory Evolution and Rare Reversal of Phage Resistance.

ABSTRACT: Bacteria and lytic viruses (phages) engage in highly dynamic coevolutionary interactions over time, yet we have little idea of how transient selection by phages might shape the future evolutionary trajectories of their host populations. To explore this question, we generated genetically diverse phage-resistant mutants of the bacterium Pseudomonas syringae. We subjected the panel of mutants to prolonged experimental evolution in the absence of phages. Some populations re-evolved phage sensitivity, whereas others acquired compensatory mutations that reduced the costs of resistance without altering resistance levels. To ask whether these outcomes were driven by the initial genetic mechanisms of resistance, we next evolved independent replicates of each individual mutant in the absence of phag

SUBMITTER: Debray R 

PROVIDER: S-EPMC9447851 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature