Origination of LTR Retroelement-Derived NYNRIN Coincides with Therian Placental Emergence.

ABSTRACT: The emergence of the placenta is a revolutionary event in the evolution of therian mammals, to which some LTR retroelement-derived genes, such as PEG10, RTL1, and syncytin, are known to contribute. However, therian genomes contain many more LTR retroelement-derived genes that may also have contributed to placental evolution. We conducted large-scale evolutionary genomic and transcriptomic analyses to comprehensively search for LTR retroelement-derived genes whose origination coincided with therian placental emergence and that became consistently expressed in therian placentae. We identified NYNRIN as another Ty3/Gypsy LTR retroelement-derived gene likely to contribute to placental emergence in the therian stem lineage. NYNRIN knockdown inhibited the invasion of HTR8/SVneo invasive-type tro

SUBMITTER: Plianchaisuk A 

PROVIDER: S-EPMC9447858 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature