Sex differences in saliva-based DNA methylation changes and environmental stressor in young African American adults.

ABSTRACT:

Background

Low socioeconomic status neighborhood exposure to stress and violence may be sources of negative stimuli that poses significant health risks for children, adolescents and throughout the life course of an individual. The study aims to investigate if aberrant epigenetic DNA methylation changes may be a potential mechanism for regulating neighborhood exposures and health outcomes.

Methods

Exposure to environmental stressors identified in 98 young African American (AA) adults aged 18-25 years old from the Washington D.C., area were used in the study. We correlated the association between stress markers; cortisol, CRP, IgG, IGA, IgM, and self-reported exposure to violence and stress, with quantitative DNA methylation changes in a panel of gene-specific loci using saliv

SUBMITTER: Saadatmand F 

PROVIDER: S-EPMC9447871 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature